{"id":8042,"date":"2020-12-07T16:31:00","date_gmt":"2020-12-07T15:31:00","guid":{"rendered":"https:\/\/proviron.com\/?post_type=resources&p=8042"},"modified":"2021-12-07T17:29:07","modified_gmt":"2021-12-07T16:29:07","slug":"added-value-of-esterified-organic-acids","status":"publish","type":"resources","link":"https:\/\/proviron.com.cn\/en\/resources\/added-value-of-esterified-organic-acids\/","title":{"rendered":"Added value of esterified organic acids"},"content":{"rendered":"\t\t
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technical article - gut health 58 <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Added value of esterified organic acids<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The financial success of animal rearing is directly related to gut health. To avoid performance losses, it is of utmost importance for farmers and veterinarians to
closely monitor the development of the gut mucosa and associated microbiota.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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dec. 2020 – Antibiotic Reduction Special 2021 | by Dr. Julie Feyaerts, Product Development Manager Proviron\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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The intestine is the most predominant gate between expensive feed input and qualitative production out put. The huge surface area of the intestinal mucosa is constantly in direct contact with the luminal content.
This mucosal barrier is providing an adequate protection against the invasion of pathogenic bacteria, viruses and toxins, but is also assuring an optimal absorption of nutrients. Fulfilling both functions simultaneously requires a well-balanced
-rich and diversified- microbiome composition, specifically located along the intestinal tract. Any factor compromising the intestinal mucosa\u2019s integrity and microbial balance will affect animal health and performance in commercial operations.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Organic acids<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Organic acids are widely present in nature. They occur in plants, animals and humans, and are produced by intestinal bacterial fermentation of fibres, starches and sugar. Organic acids are called Short Chain Fatty Acids (SCFA) when containing less than 6 carbon atoms, and Mid Chain Fatty Acids (MCFA) when containing 6 to 14 carbon atoms. Some organic acids have a long history of use as preservative. The antimicrobial action of organic acids as preservative in feed or drinking water occurs through lowering the pH, reducing the feeds buffering capacity and affecting the microbial population in feed or water. More important, however, is the fact that organic acids can also have beneficial effects inside an animal\u2019s digestive tract by steering the complex\u00a0intestinal microbial community and enhancing the integrity\u00a0<\/span>of the intestinal mucosa.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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The added value of esterification of SCFA\u2019s and MCFA\u2019s.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Esterified butyric acid\n\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Butyric acid plays a fundamental role in the development, integrity and functionality of the gut of birds and mammals, and has received particular attention for its extraordinary beneficial effects on animal health. In order for butyric acid to improve animal gut health, it should ideally be delivered gradually along the GIT. Unfortunately, as butyric acid is a very small molecule, it gets readily absorbed in the stomach and the upper part of the small intestine, hence not reaching the entire intestine. A novel and proven technology to gradually deliver butyric acid along the GIT is known as \u201cesterification\u201d.<\/p>

Esterification is a chemical process allowing the binding of one glycerol molecule to 1, 2 or 3 organic acid molecules, forming mono-, di- or triglycerides of organic acids. Typical examples of esterified forms of butyric acid are monoglycerol butyrate, or monobutyrin, and triglycerol butyrate, or tributyrin. Both are extensively used in animal production. Monobutyrin and tributyrin have the advantage compared to free butyric acid and its salts that they do not smell, are noncorrosive, are pH independent and are gradually released throughout the entire gut by enzymatic activity of pancreatic lipases.<\/p>

Worldwide scientific research and trials have confirmed the substantial benefits of butyric acid esterification, i.e. improved gut morphology, enhanced gut integrity, augmented nutrient digestion and absorption, and balanced immune system and luminal microbiota. These multifactorial benefits make mono- and tributyrins a globally accepted and widely used tool in managing optimal gut health.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Esterified MCFA\u2019s<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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For many years, MCFA\u2019s have been thoroughly investigated\u00a0for their antibacterial and antiviral potential. Extended in vitro research indicated that the esterified monoglyceride form of\u00a0a MCFA has superior antimicrobial activity compared to the\u00a0non-esterified free mid chain fatty acid. Research also showed\u00a0that the di- and triglyceride form of a MCFA has no antibacterial action and even inhibits the antibacterial activity of a\u00a0monoglyceride when they co-occur.\u00a0<\/p>

Thanks to the amphiphilic nature of monoglycerides, the\u00a0membrane of bacteria and the lipid envelope of viruses can\u00a0be destroyed, consequently killing the pathogens. The longer\u00a0the MCFA monoglyceride, the higher the antibacterial activity\u00a0against Gram-positive bacteria, for instance glycerol\u00a0monocaproate (C6) < glycerol monocaprylate (C8) < glycerol\u00a0monocaprate (C10) < glycerol monolaurate (C12). Gramnegative bacteria are known to be more sensitive to shorter\u00a0MCFA monoglycerides.<\/p>

Due to the worldwide increasing antimicrobial resistance\u00a0awareness, the industry has intensively explored alternatives\u00a0to reduce the use of antibiotic growth promoters in livestock production. A consensus amongst scientists and veterinarians\u00a0exists in the fact that a multifaceted approach is required to\u00a0produce healthy animals without extensive use of in-feed antibiotics. Esterified MCFA\u2019s are a -scientifically and commercially- proven and popular in-feed solution thanks to their\u00a0strong antibacterial, antiviral and immunity enhancing effects. Adding MCFA esters to the feed avoids excessive inflammation at gut level and generates a more resilient microbiome. This results into increased vaccination efficiency and\u00a0higher animal performance, without antimicrobial resistance.<\/span>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Conclusion<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Modern antibiotic-lean animal farming relies on a well-oiled\u00a0approach, bringing together good manufacturing practices,\u00a0highly evolved genetics and optimised diets. Specialty feed\u00a0ingredients are an essential part of these diets. It is\u00a0increasingly recognised and accepted that financial success\u00a0of animal rearing is directly linked to animal health in general\u00a0and intestinal health more specifically. Carefully selecting the\u00a0right type and combination of ingredients is vital. Many years\u00a0of research and development by Proviron and others have\u00a0indisputably demonstrated that the selective esterification of\u00a0organic acids adds major benefits both inside and outside the\u00a0animal. Each animal production has its own particular\u00a0challenges. These can be met by using different types\/forms\/combinations\/dosages of glycerides, each having different
modes of action. It is highly recommended and useful for\u00a0farmers, veterinarians and nutritionists to request\u00a0professional advice in selecting the most appropriate
products for their specific needs. Proviron -having many years\u00a0of experience and know-how in Animal Health- manufactures\u00a0high purity fatty acid esters (pureLine range) and patented\u00a0gut health improving concepts for poultry (Optigut), swine\u00a0(Porcestin) and aquaculture (Optigut Aqua), emphasising the\u00a0synergistic effects of combining carefully selected ingredients\u00a0for specific animal challenges.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tthe article on 'gut heatlh'<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\tNext<\/span>use of monoglycerides popular<\/span><\/span><\/i>Next<\/span><\/span><\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"author":9,"featured_media":0,"template":"elementor_theme","resource-types":[63],"class_list":["post-8042","resources","type-resources","status-publish","hentry","resource-types-animal-health"],"yoast_head":"\nAdded value of esterified organic acids - proviron<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/proviron.com.cn\/resources\/added-value-of-esterified-organic-acids\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Added value of esterified organic acids - proviron\" \/>\n<meta property=\"og:description\" content=\"technical article – gut health 58 Added value of esterified organic acids The financial success of animal rearing is directly related to gut health. 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